Which allele is linked to recovery from TBI?

The allele linked to recovery from traumatic brain injury (TBI) is the E4 allele of the apolipoprotein E (ApoE) gene. Research has indicated that the presence of the E4 allele can influence cognitive outcomes following brain injuries. Specifically, individuals with this allele may have a poorer prognosis and a harder time in recovery due to its association with neurodegenerative processes and increased susceptibility to cognitive decline after such injuries.

In contrast, other alleles, such as E2 and E3, have been considered in relation to recovery but are not as strongly correlated with adverse outcomes as E4. The E2 allele has been shown to have some protective effects and may support better recovery, while E3 is generally considered neutral concerning TBI outcomes. The distinction in recovery linked to the alleles is significant in the context of neurobiology and highlights the complex interplay between genetics and brain injury recovery.